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3D Matrix for Bioprinting/Biotechnology lab

The cells are always in the 3D micro-environment in vivo and cell–ECM (extra cellular matrix) construct (tissue) are self-renewable. Therefore rapid cell expansion with maintenance of specific cell lineage is possible only in 3D matrices.
During cell expansion, the 3D matrix could be used as 3D microenvironment for the cells and their expansion. Further, this 3D scaffold should facilitate easy separation of cells from the matrix by playing as sacrificial substrate for effective collection of the cells prior to cell delivery in vivo. Ideally, the 3D matrix should act as a transient material and easily disappear to assist cell accumulation. Therefore, cell culture approaches should rely on transient 3D matrices/scaffolds that provide support similar to the native extracellular matrix. Use of 3D microenvironment, scaffold and bioreactors are effective in maintaining cell lineage for several generations for their expansion and applications in the direction of cell delivery.
Different forms of 3D matrices like 3D sponge, beads, sheet, gel, fibre, 3D printing premix etc. are offered for various cell biology and biotechnology studies such as live cell printing, bioprinting 3D cell culture, in vitro tissue formation, cell expansion in 3D microenvironment and drug testing in bioreactor model.
The 3D matrix could be used for cell expansion and cells could also be recovered using the following scheme -